Literaturverzeichnis
Kapitel 1 – Kein Leben ohne Sonne
- Dobzhansky T (1973). Nothing in Biology Makes Sense Except in the Light of Evolution, American Biology Teacher, 35 (3): 125–129, JSTOR 4444260; reprinted in Zetterberg, J. Peter, ed. (1983), Evolution versus Creationism, Phoenix, Arizona: ORYX Press
- Planet-Schule: https://www.planet-schule.de/mm/die-erde/Barrierefrei/pages/Die_Anfaenge_der_Erde.html
- Bernhard Kegel: Die Herrscher der Welt. Wie Mikroben unser Leben bestimmen. ISBN 978-3832197735, DuMont Buchverlag, Köln 2015
- Sven Böttcher: Rette sich, wer kann: Das Krankensystem meiden und gesund bleiben. ISBN 978-3954716388, ABOD Verlag, München 2019
- Peter C. Gøtzsche: Tödliche Medizin und organisierte Kriminalität: Wie die Pharmaindustrie unser Gesundheitswesen korrumpiert. ISBN 978-3742311610, Riva Verlag, München 2019
- Dr. Gerd Reuther: Der betrogene Patient: Ein Arzt deckt auf, warum Ihr Leben in Gefahr ist, wenn Sie sich medizinisch behandeln lassen. ISBN 978-3742310347, Riva Verlag, München 2019
- Ulrike von Aufschnaiter: Deutschlands Kranke Kinder: Wie auf Anweisung der Regierung Kitas und Schulen die Gesundheit unserer Kinder schädigen. ISBN 978-3748262374, tredition Verlag, Hamburg 2019
- Eva Herman: Die Wahrheit und ihr Preis: Meinung, Macht und Medien. ISBN 978-3942016285, Kopp Verlag, Rottenburg a.N. 2010
- Rainer Mausfeld: Warum schweigen die Lämmer? ISBN 978-3864892776, Westend Verlag, Wiesbaden 2019
Abb.1: enriquelopezgarre, www.pixabay.com
Abb.2: Emde Grafik, Copyright AMM
Kapitel 2 – Nationaler und internationaler Vitamin D-Mangel
- National Center for Biotechnology Information. PubMed Single Citation Matcher [homepage on the Internet]: U.S. National Library of Medicine; National Institutes of Health; 2008. Internet: http://www.ncbi.nlm.nih.gov/entrez/query/static/citmatch.html (updated 09 May 2008; accessed 14 Jul 2008)
- Hintzpeter B, Mensink GB et al. Vitamin D status and health correlates among German adults. European journal of clinical nutrition 2007
- Hintzpeter, B et al. Zitat 3: Eigenschaft des Vitamin D im Kindesalter. Proceedings of the German Nutrition Society 10 2007;10:47
- Hintzpeter B, Scheidt-Nave C et al. Higher prevalence of vitamin D deficiency is associated with immigrant background among children and adolescents in Germany. J Nutr. 2008 Aug;138(8):1482-90
- Puri S, Agarwala N et al. Vitamin D status of apparently healthy schoolgirls from two different socioeconomic strata in Delhi: relation to nutrition and lifestyle. British Journal of Nutrition 2008;99(4):876–82
- Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. The American journal of clinical nutrition 2007;85(3):860–8
- Woo J, Lam CW et al. Very high rates of vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong. The British Journal of Nutrition 2008;99(6):1330–4
- Islam MZ, Akhtaruzzaman M, Lamberg-Allardt C. Hypovitaminosis D is common in both veiled and nonveiled Bangladeshi women. Asia Pacific journal of clinical nutrition 2006;15(1):81–7.
- Scheidt-Nave C, Hintzpeter B et al (2015). Vitamin D status among adults in Germany–results from the German Health Interview and Examination Survey for Adults (DEGS1). In: BMC public health 15, S. 641. DOI: 10.1186/s12889-015-2016-7
- Robert Koch-Institut, Berlin – Gert B.M. Mensink, Clarissa Lage Barbosa, Anna-Kristin Brettschneider. Journal of Health Monitoring 2016 1(2) DOI 10.17886/RKI-GBE-2016-033
- Göthel, Christopher (2020, May 08). Entwicklung der Epidemiologie und der jahreszeitlichen Abhängigkeit des Vitamin-D-Status in Deutschland in den Jahren 2007 bis 2019. Retrieved June 25, 2020, from https://tore.tuhh.de/handle/11420/6400
- Mehany S, Pöppelmeyer C et al. Niedrige Vitamin-D-Blutspiegel in Wiener Schulkindern. EDDY Studie, Aktuel Ernahrungsmed 2015; 40 – P2_3. DOI: 10.1055/s-0035-1550200
- Gellert S, Strohle A et al (2017). Higher prevalence of vitamin D deficiency in German pregnant women compared to non-pregnant women. In: Archives of gynecology and obstetrics 296 (1), S. 43–51. DOI: 10.1007/s00404-017-4398-5
- Cashman KD, Gonzalez-Gross M et al (2016). Vitamin D deficiency in Europe: pandemic? Retrieved from https://academic.oup.com/ajcn/article/103/4/1033/4662891
- Li H, Xiao P et al (2020). Widespread vitamin D deficiency and its sex-specific association with adiposity in Chinese children and adolescents. Nutrition, 71, 110646. DOI: 10.1016/j.nut.2019.110646
- Mirfakhraee S et al (2017). Longitudinal changes in serum 25-hydroxyvitamin D in the Dallas Heart Study. Clin Endocrinol (Oxf)
- Galior K, Ketha H et al (2018). 10 years of 25-hydroxyvitamin-D testing by LC-MS/MS-trends in vitamin-D deficiency and sufficiency. Bone Reports, 8, 268–273. DOI: 10.1016/j.bonr.2018.05.003
- Cashman KD, Kiely M (2018). Contribution of nutrition science to the vitamin D field—Clarity or confusion? The Journal of Steroid Biochemistry and Molecular Biology. DOI:10.1016/j.jsbmb.2018.10.020
Kapitel 3 – Der Vitamin D-Stoffwechsel
- Holick MF. Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. Biochemistry 1971;10(14):2799–804
- Lawson DEM, Fraser DR, Kodicek E, Morris HR, Williams DH. Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism. Nature 1971;230(5291):228.230
- Brumbaugh PF, Haussler MR. Nuclear and cytoplasmic binding components for vitamin D metabolites. Life sciences 1975;16(3):353–62
- Die Bedeutung der Vitamin D – Vitamin D-Rezeptor-Achse in der Aktivierung der humanen hepatischen Sternzellen; https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00038454/Dissertation_Beilfuss.pdf
- DeLuca HF, Darwish HM, Ross TK, Moss VE. Mechanism of action of 1,25-dihydroxyvitamin D on target gene expression. Journal of nutritional science and vitaminology 1992;19-26
- Kauer H. Vitamin D in Immunologie und Onkologie – Eine Literaturstudie. [Dissertation]. München: LMU München; 09.02.2007
- Hollis BW et al (2013). The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes. In: The Journal of clinical endocrinology and metabolism 98 (12), S. 4619–4628. DOI: 10.1210/jc.2013-2653
- Ginde AA, Wolfe P et al. Defining vitamin D status by secondary hyperparathyroidism in the U.S. population, Journal of Endocrinological Investigation 2012, 35, pages 42–48
- Domarus C, Brown J et al. How much vitamin D do we need for skeletal health? In: Clinical orthopaedics and related research 469 (2011), S. 3127–3133
- Hollis BW et al (2015). Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. In: Pediatrics 136 (4), S. 625–634. DOI: 10.1542/peds.2015-1669
- Hollis BW, Wagner CL et al (2006). High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. In: Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine 1 (2), S. 59–70. DOI: 10.1089/bfm.2006.1.59
- Dawodu A, Salameh KM et al (2019). The Effect of High-Dose Postpartum Maternal Vitamin D Supplementation Alone Compared with Maternal Plus Infant Vitamin D Supplementation in Breastfeeding Infants in a High-Risk Population. A Randomized Controlled Trial. Nutrients, 11(7), 1632. DOI:10.3390/nu11071632
- Garland CF, Kim JJ et al (2014). Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24922127
- Teixeira DS, Nobrega YKM et al (2012). Evaluation of 25-hydroxy-vitamin D and parathyroid hormone in Callithrix penicillata primates living in their natural habitat in Brazil. Journal of Medical Primatology, 41(6), 364–371. DOI: 10.1111/jmp.12021
- Power ML, Dittus WP (2017). Vitamin D status in wild toque macaques (Macaca sinica) in Sri Lanka. American Journal of Primatology, 79(6). DOI:10.1002/ajp.22655
- Luxwolda MF, Kuipers, RS et al (2012). Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. British Journal of Nutrition, 108(9), 1557–1561. DOI: 10.1017/s0007114511007161
- Shirvan A, Holick MF et al (2019). Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial. Scientific Reports, 9(1). DOI: 10.1038/s41598-019-53864-1
- Shaat N, Kristensen K et al (2020). Association between the rs1544410 polymorphism in the vitamin D receptor (VDR) gene and insulin secretion after gestational diabetes mellitus. Plos One, 15(5). DOI: 10.1371/journal.pone.0232297
- Pereira‐Santos M, Oliveira AM et al (2019). Polymorphism in the vitamin D receptor gene is associated with maternal vitamin D concentration and neonatal outcomes: A Brazilian cohort study. American Journal of Human Biology. DOI: 10.1002/ajhb.23250
- Abd-Elsalam S, Mohamed A, El-Adawy E et al (2019). Association of serum level of vitamin D and VDR polymorphism Fok1 with the risk or survival of pancreatic cancer in Egyptian population. Indian Journal of Cancer, 56(2), 130. DOI: 10.4103/ijc.ijc_299_18
- Yang SK, Song N, Zhang H et al (2019). Association of Vitamin D Receptor Gene Polymorphism With the Risk of Nephrolithiasis. Therapeutic Apheresis and Dialysis, 23(5), 425–436. DOI: 10.1111/1744-9987.12797
- Ahmed J, Makonnen E et al (2019). Vitamin D Status and Association of VDR Genetic Polymorphism to Risk of Breast Cancer in Ethiopia. Nutrients, 11(2), 289. DOI: 10.3390/nu11020289
- Carlberg C, Haq A (2016). The concept of the personal vitamin D response index. In: The Journal of steroid biochemistry and molecular biology. DOI: 10.1016/j.jsbmb.2016.12.011
- Finamor DC, Sinigaglia-Coimbra R et al (2013). A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. In: Dermato-endocrinology 5 (1), S. 222–234. DOI: 10.4161/derm.24808
Videoempfehlung: Fit mit Fett – ein Leben lang – Vortrag von Prof. Dr. med. Jörg Spitz
https://www.youtube.com/watch?v=xwSPLAkkRYc
Abb. 2: siehe Nr. 9
Kapitel 4 – Kofaktoren für Vitamin D
- Schimatschek HF, Rempis R (2001). Prevalence of hypomagnesemia in an unselected German population of 16,000 individuals. Magnesium research: official organ of the International Society for the Development of Research on Magnesium, 14. Jg., Nr. 4, S. 283-290
- Rosanoff A, Weaver CM et al (2012). Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutrition reviews 70.3: 153-164
- Medalle R, Waterhouse C et al (1976). Vitamin D resistance in magnesium deficiency. The American Journal of Clinical Nutrition, 29(8), 854-858. DOI:10.1093/ajcn/29.8.854
- Theuwissen E, Cranenburg EC et al (2012). Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. British Journal of Nutrition, 108(09), 1652-1657. DOI:10.1017/s0007114511007185
- Kim S, Kim K et al (2010). Correlation of Undercarboxylated Osteocalcin (ucOC) Concentration and Bone Density with Age in Healthy Korean Women. Journal of Korean Medical Science, 25(8), 1171. DOI:10.3346/jkms.2010.25.8.1171
- Nakano T, Tsugawa N et al (2011). High prevalence of hypovitaminosis D and K in patients with hip fracture. Department of Health and Nutrition, Osaka Shoin Women’s University, 4-2-26 Hishiyanishi, Higashiosaka-shi, Osaka 577-8550 Japan
- Fujita Y, Iki M et al (2011). Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. Osteoporosis International, 23(2), 705-714. DOI:10.1007/s00198-011-1594-1
- Iwamoto J, Sato Y et al (2009). High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: A review of the literature. Nutrition Research, 29(4), 221-228. DOI:10.1016/j.nutres.2009.03.012
- Yamaguchi M (2010). Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation. International Journal of Molecular Medicine. DOI:10.3892/ijmm.2010.562
- Forli L, Bollerslev J et al (2010). Dietary Vitamin K2 Supplement Improves Bone Status After Lung and Heart Transplantation. Transplantation, 89(4), 458-464. DOI:10.1097/tp.0b013e3181c46b69
- Booth SL, Gundberg C et al (2004). Associations between Vitamin K Biochemical Measures and Bone Mineral Density in Men and Women. The Journal of Clinical Endocrinology & Metabolism, 89(10), 4904-4909. DOI:10.1210/jc.2003-031673
- Gröber U, Holick MF et al (2013). Vitamin D. Dermato-Endocrinology, 5(3), 331-347. DOI:10.4161/derm.26738
- Cantorna MT, Snyder L et al (2019). Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Critical Reviews in Biochemistry and Molecular Biology, 54(2), 184–192. DOI: 10.1080/10409238.2019.1611734
Titelbild: Gerd Altmann, www.pixabay.com
Kapitel 5 – Die Bedeutung von Vitamin D am Anfang des Lebens
- Voulgaris N, Papanastasiou L et al (2017). Vitamin D and aspects of female fertility. In: Hormones (Athens, Greece) 16 (1), S. 5–21. DOI: 10.14310/horm.2002.1715
- Miliku K, Burne TH et al (2016). Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. In: The American journal of clinical nutrition 103 (6), S. 1514–1522. DOI: 10.3945/ajcn.115.123752
- Qin LL, Fang-Guo Y et al (2016). Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies. In: Nutrients 8 (5). DOI: 10.3390/nu8050301
- Cantorna MT, Mahon BD (2004). Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. In: Experimental biology and medicine (Maywood, N.J.) 229 (11), S. 1136–1142
- Dankers W, Edgar M et al (2016). Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential. In: Frontiers in immunology 7, S. 697. DOI: 10.3389/fimmu.2016.00697
- Gellert S, Bitterlich N et al (2017). Higher prevalence of vitamin D deficiency in German pregnant women compared to non-pregnant women. In: Archives of gynecology and obstetrics 296 (1), S. 43–51. DOI: 10.1007/s00404-017-4398-5
- Wagner CL, Baggerly C et al (2016). Post-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009-2011 rates. In: The Journal of steroid biochemistry and molecular biology 155 (Pt B), S. 245–251. DOI: 10.1016/j.jsbmb.2015.10.022
- Hollis BW, Wagner CL (2013). The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes. In: The Journal of clinical endocrinology and metabolism 98 (12), S. 4619–4628. DOI: 10.1210/jc.2013-2653
- Holick MF, Bischoff-Ferrari HA et al (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. In: The Journal of clinical endocrinology and metabolism 96 (7), S. 1911–1930. DOI: 10.1210/jc.2011-0385
- GrassrootsHealth Nutrient Research Institute (2018): https://www.grassrootshealth.net/wp-content/uploads/2017/01/MRIP-chart-booklet-08-2018.pdf
- Hollis BW, Wagner CL et al (2015). Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. In: Pediatrics 136 (4), S. 625–634. DOI: 10.1542/peds.2015-1669
- Wagner CL, Hollis BW et al (2006). High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. In: Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine 1 (2), S. 59–70. DOI: 10.1089/bfm.2006.1.59
- Voulgaris N, Papanastasiou L et al (2017). Vitamin D and aspects of female fertility. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28500824
- Menichini D, Facchinetti F (2019). Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review. Gynecological Endocrinology, 1–5. DOI: 10.1080/09513590.2019.1625881
- Gellert S, Bitterlich N et al (2017). Higher prevalence of vitamin D deficiency in German pregnant women compared to non-pregnant women. In: Archives of gynecology and obstetrics 296 (1), S. 43–51. DOI: 10.1007/s00404-017-4398-5
- Abulebda K, Abu-Sultaneh S, Lutfi R (2017. It is not always child abuse. Multiple fractures due to hypophosphatemic rickets associated with elemental formula use. In: Clinical case reports 5 (8), S. 1348–1351. DOI: 10.1002/ccr3.1052
- Cannell JJ, Holick MF (2018). Multiple unexplained fractures in infants and child physical abuse. In: The Journal of steroid biochemistry and molecular biology 175, S. 18–22. DOI: 10.1016/j.jsbmb.2016.09.012
- Ulrike von Aufschnaiter – Deutschlands Kranke Kinder: Wie auf Anweisung der Regierung Kitas und Schulen die Gesundheit unserer Kinder schädigen; ISBN 978-3748262374, tredition Verlag, Hamburg 2019
- Kühnisch J, Thiering E et al (2014). Elevated Serum 25(OH)-Vitamin D Levels Are Negatively Correlated with Molar-Incisor Hypomineralization. Journal of Dental Research, 94(2), 381–387. DOI: 10.1177/0022034514561657
- Schroth R, Moffat M et al (2015). Vitamin D and Dental Caries in Children. Journal of Dental Research, 95(2), 173–179. DOI: 10.1177/0022034515616335
- Wolsk HM, Harshfield BJ et al (2017). Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial. In: The Journal of allergy and clinical immunology. DOI: 10.1016/j.jaci.2017.01.013
Titelbild: amyelizabethquinn, www.pixabay.com
Abb. 4: Creative Commons Attribution (CC BY 4.0)
Kapitel 6.1 – Vitamin D und Immunsystem
- Chirumbolo S, Bjorklund G et al (2017). The Role of Vitamin D in the Immune System as a Pro-survival Molecule. In: Clinical therapeutics 39 (5), S. 894–916. DOI: 10.1016/j.clinthera.2017.03.021
- Venturini E, Facchini L et al (2014). Vitamin D and tuberculosis. A multicenter study in children. In: BMC infectious diseases 14, S. 652. DOI: 10.1186/s12879-014-0652-7
- Arnedo-Pena A, Garcia-Ferrer D et al (2015). Vitamin D status and incidence of tuberculosis among contacts of pulmonary tuberculosis patients. In: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 19 (1), S. 65–69. DOI: 10.5588/ijtld.14.0348
- Villar LM, Del Campo JA et al (2013). Association between vitamin D and hepatitis C virus infection. A meta-analysis. In: World journal of gastroenterology 19 (35), S. 5917–5924. DOI: 10.3748/wjg.v19.i35.5917
- Garcia-Alvarez M, Pineda-Tenor D et al (2014). Relationship of vitamin D status with advanced liver fibrosis and response to hepatitis C virus therapy. A meta-analysis. In: Hepatology (Baltimore, Md.) 60 (5), S. 1541–1550. DOI: 10.1002/hep.27281
- Cusick SE, Polgreen LE et al (2014). Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. In: PloS one 9 (12), e113185. DOI: 10.1371/journal.pone.0113185
- Cannell JJ, Holick MF et al. Epidemic influenza and vitamin D. Epidemiology and infection 2006;134(6):1129–40
- Laaksi I, Ruohola JP et al. An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men. American Journal of Clinical Nutrition 2007;86(3):714–7
- Li Y C, Chen Y et al (2015). Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation. The Journal of Steroid Biochemistry and Molecular Biology, 148, 179–183. DOI: 10.1016/j.jsbmb.2015.01.011
- Dimitrov V, White JH (2017). Vitamin D signaling in intestinal innate immunity and homeostasis. Molecular and Cellular Endocrinology, 453, 68-78. DOI:10.1016/j.mce.2017.04.010
- Kocovska E, Gaughran F et al (2017). Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism. In: Frontiers in psychiatry 8, S. 47. DOI: 10.3389/fpsyt.2017.00047
- Gominak S. (2016). Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with atherosclerosis and autoimmunity. Medical Hypotheses, 94, 103-107. DOI:10.1016/j.mehy.2016.07.007
- Quraishi SA, Needleman JS et al (2015). Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis. Critical Care Medicine, 43(9), 1928–1937. DOI: 10.1097/ccm.0000000000001148
- Grant WB, Baggerly CA et al (2020). Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients, 12(4), 988. DOI:10.3390/nu12040988
- Kara M et al. Scientific Strabismus’ or Two Related Pandemics: COVID-19 & Vitamin D Deficiency. British Journal of Nutrition, 2020, pp. 1–20., DOI:10.1017/s0007114520001749
- Li X et al. Risk Factors for Severity and Mortality in Adult COVID-19 Inpatients in Wuhan. Journal of Allergy and Clinical Immunology, 2020, DOI:10.1016/j.jaci.2020.04.006
- Mark M. Alipio, Department of Radiologic Technology, College of Allied Health Sciences: Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Coronavirus-2019 (Covid-2019), 2020
- Kaufman HW, Holick MF et al (2020). SARS-CoV-2-Positivitätsraten in Verbindung mit zirkulierenden 25-Hydroxyvitamin D-Spiegeln. PLoS ONE 15 (9): e0239252. https://doi.org/10.1371/journal.pone.0239252
- Radujkovic A, Hippchen T et al (2020). Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients, 12(9), 2757. doi:10.3390/nu12092757
- https://vitamindwiki.com/COVID-19+Coronavirus+can+most+likely+be+fought+by+Vitamin+D#Intervention
- Castillo M et al. (2020). Effect of Calcifediol Treatment and best Available Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study. Retrieved from https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub
- Murdaca G, Tonacci A et al (2019). Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications. Autoimmunity Reviews, 18(9), 102350. DOI: 10.1016/j.autrev.2019.102350
- Acheson ED, Bachrach CA. The distribution of multiple sclerosis in U. S. veterans by birthplace. American journal of hygiene 1960;72:88–99
- Kurtzke JF. On the fine structure of the distribution of multiple sclerosis. Acta Neurol Scand. Acta neurologica Scandinavica 1967;43(3):257–82
- Dean G (1974). Diet And Geographical Distribution Of Multiple Sclerosis. The Lancet, 304(7894), 1445. DOI: 10.1016/s0140-6736(74)90091-9
- Munger KL, Hollis BW et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA, The Journal of the American Medical Association 2006;296(23):2832–8
- Van der Mei IA, Ponsonby AL et al. Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia. Journal of neurology 2007;254(5):581–90
- Kampman M, Wilsgaard T, Mellgren S. Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle. Journal of neurology 2007;254(4):471–7
- Smolders J, Damoiseaux J et al. Vitamin D as an immune modulator in multiple sclerosis, a review. Journal of neuroimmunology 2008;194(1-2):7–17
- Niino M, Fukazawa T et al. Therapeutic potential of vitamin d for multiple sclerosis. Current medicinal chemistry 2008;15(5):499–505
- Smolders J, Moen SM et al (2011). Vitamin D in the healthy and inflamed central nervous system. Access and function. In: Journal of the neurological sciences 311 (1-2), S. 37–43. DOI: 10.1016/j.jns.2011.07.033
- Pierrot-Deseilligny C, Souberbielle JC (2017). Vitamin D and multiple sclerosis. An update. In: Multiple sclerosis and related disorders 14, S. 35–45. DOI: 10.1016/j.msard.2017.03.014
- Burton JM, Kimball S et al (2010). A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. In: Neurology 74 (23), S. 1852–1859. DOI: 10.1212/WNL.0b013e3181e1cec2
- Stewart N, Simpson S et al (2012). Interferon- and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS. Neurology, 79(3), 254–260. DOI: 10.1212/wnl.0b013e31825fded9
- Laursen JH, Sondergaard HB et al (2016). Vitamin D supplementation reduces relapse rate in relapsing-remitting multiple sclerosis patients treated with natalizumab. In: Multiple sclerosis and related disorders 10, S. 169–173. DOI: 10.1016/j.msard.2016.10.005
- Bjorksten F, Suoniemi I (1976). Dependence of immediate hypersensitivity on the month of birth. Clinical Experimental Allergy, 6(2), 165-171. DOI:10.1111/j.1365-2222.1976.tb01894.x
- Matsui T, Tanaka K et al (2019). Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency. Allergology International, 68(2), 172-177. DOI:10.1016/j.alit.2018.12.003
- Sharief S, Jariwala S et al (2011). Vitamin D levels and food and environmental allergies in the United States: Results from the National Health and Nutrition Examination Survey 2005-2006. Journal of Allergy and Clinical Immunology, 127(5), 1195-1202. DOI:10.1016/j.jaci.2011.01.017
- Wu D et al. Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance. Frontiers in Immunology, vol. 9, 2019, DOI:10.3389/fimmu.2018.03160
- Uwe Gröber, Orthomolekulare Medizin – Ein Leitfaden für Apotheker und Ärzte, ISBN 978-3804719279, Wissenschaftliche Verlagsgesellschaft, Stuttgart 2015
- Oliveira L et al. Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases. Mediators of Inflammation, vol. 2018, 2018, pp. 1–17., DOI:10.1155/2018/3067126
- Carr A, Maggini S. Vitamin C and Immune Function. Nutrients, vol. 9, no. 11, 2017, p. 1211., DOI:10.3390/nu9111211
- Wang Y, Washko W et al (1996). Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Retrieved from https://www.pnas.org/content/93/8/3704
- Cheng RZ. Can Early and High Intravenous Dose of Vitamin C Prevent and Treat Coronavirus Disease 2019 (COVID-19)? Medicine in Drug Discovery, vol. 5, 2020, p. 100028., DOI:10.1016/j.medidd.2020.100028
- Avery J, Hoffmann P. Selenium, Selenoproteins, and Immunity. Nutrients, vol. 10, no. 9, 2018, p. 1203., DOI:10.3390/nu10091203
- Gammoh NZ, Rink L. Zinc in Infection and Inflammation. Nutrients, vol. 9, no. 6, 2017, p. 624., DOI:10.3390/nu9060624
- Calabrese LH. Cytokine Storm and the Prospects for Immunotherapy with COVID-19. Cleveland Clinic Journal of Medicine, 2020, p. ccc008., DOI:10.3949/ccjm.87a.ccc008
- Miyajima M. Amino Acids: Key Sources for Immunometabolites and Immunotransmitters. International Immunology, 2020, DOI:10.1093/intimm/dxaa019
- Shah AM et al. Glutamine Metabolism and Its Role in Immunity, a Comprehensive Review. Animals, vol. 10, no. 2, 2020, p. 326., DOI:10.3390/ani10020326
Titelbild 6.1.1: Ria Sopala, www. pixabay.com
Abb. 1: nach Nr. 1, mit freundlicher Genehmigung von Hevert GmbH
Titelbild 6.1.2: Colin Behrens, www.pixabay.com
Kapitel 6.2 – Vitamin D und Skelett und Knochen
- Gani LU, How CH (2015). PILL Series. Vitamin D deficiency. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545131/
- Dawson-Hughes B, Harris S et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. The New England journal of medicine 1997;337(10):670–6
- Wacker M, Holick M F (2013). Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571641/
- Kuwabara A, Tanaka K (2015). The role of gastro-intestinal tract in the calcium absorption. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26503863
- Bronner F (2002). Mechanisms of intestinal calcium absorption. Journal of Cellular Biochemistry, 88(2), 387–393. DOI: 10.1002/jcb.10330
- Christakos . (2012). Recent advances in our understanding of 1,25-dihydroxyvitamin D3 regulation of intestinal calcium absorption. Archives of Biochemistry and Biophysics, 523(1), 73–76. DOI: 10.1016/j.abb.2011.12.020
- Heaney RP, Dowell MS et al (2003). Calcium Absorption Varies within the Reference Range for Serum 25-Hydroxyvitamin D. Journal of the American College of Nutrition, 22(2), 142–146. DOI: 10.1080/07315724.2003.10719287
- Ginde AA, Wolfe P et al (2012). Defining vitamin D status by secondary hyperparathyroidism in the U.S. population. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21606669.
- Domarus C, Brown J et al (2011). How much vitamin D do we need for skeletal health? In: Clinical orthopaedics and related research 469 (11), S. 3127–3133
- Göthel C (2020). Entwicklung der Epidemiologie und der jahreszeitlichen Abhängigkeit des Vitamin-D-Status in Deutschland in den Jahren 2007 bis 2019. Retrieved June 25, 2020, from https://tore.tuhh.de/handle/11420/6400
- Björn B et al. Vitamin D Deficiency Induces Early Signs of Aging in Human Bone, Increasing the Risk of Fracture, Science Translational Medicine, 10 July 2013, 5/193, p. 193ra88
Titelbild: StockSnap, www.pixabay.com
Kapitel 6.3 – Vitamin D und Sport und Muskeln
- Zhang L, Quan M et al (2019). Effect of vitamin D supplementation on upper and lower limb muscle strength and muscle power in athletes: A meta-analysis. In: PloS one 14 (4), e0215826. DOI: 10.1371/journal.pone.0215826
- Montenegro KR, Cruzat V et al (2019). Mechanisms of vitamin D action in skeletal muscle. In: Nutrition Research Reviews, S. 1–13. DOI: 10.1017/S0954422419000064
- Dzik KP, Kaczor JJ (2019). Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state. In: European journal of applied physiology 119 (4), S. 825–839. DOI: 10.1007/s00421-019-04104-x
- Aydın CG, Dinçel YM et al (2019). The effects of indoor and outdoor sports participation and seasonal changes on vitamin D levels in athletes. In: SAGE open medicine 7, 2050312119837480. DOI: 10.1177/2050312119837480
- Constantini NW, Arieli R et al (2010). High Prevalence of Vitamin D Insufficiency in Athletes and Dancers. Clinical Journal of Sport Medicine, 20(5), 368–371. DOI: 10.1097/jsm.0b013e3181f207f2
- Shuler FD, Wingate MK et al (2012). Sports Health Benefits of Vitamin D. Sports Health: A Multidisciplinary Approach, 4(6), 496–501. DOI: 10.1177/1941738112461621
- Forney LA, Earnest CP et al (2014). Vitamin D Status, Body Composition, and Fitness Measures in College-Aged Students. Journal of Strength and Conditioning Research, 28(3), 814–824. DOI: 10.1519/jsc.0b013e3182a35ed0
- Erem S (2019). Anabolic effects of vitamin D and magnesium in aging bone. In: The Journal of Steroid Biochemistry and Molecular Biology 193, S. 105400. DOI: 10.1016/j.jsbmb.2019.105400
- Reddy P, Edwards LR (2019). Magnesium Supplementation in Vitamin D Deficiency. In: American journal of therapeutics 26 (1), e124-e132. DOI: 10.1097/MJT.0000000000000538
- Trummer C, Schwetz V et al (2017). Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial. In: Nutrients 9 (6). DOI: 10.3390/nu9060623
- Gogulothu R, Nagar D et al (2019). Disrupted expression of genes essential for skeletal muscle fibre integrity and energy metabolism in Vitamin D deficient rats. The Journal of Steroid Biochemistry and Molecular Biology, 105525. DOI: 10.1016/j.jsbmb.2019.105525
Titelbild: Gentrit Sylejmani, www.unsplash.com
Kapitel 6.4 – Metabolisches Syndrom und Fettleber
- Moukayed M, Grant WB (2019). Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 12, 1437–1447. DOI: 10.2147/dmso.s176933
- Thomas GN, Bosch JA et al (2012). Vitamin D Levels Predict All-Cause and Cardiovascular Disease Mortality in Subjects With the Metabolic Syndrome: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Diabetes Care, 35(5), 1158–1164. DOI: 10.2337/dc11-1714
- Pan G-T, Guo J-F et al (2016). Vitamin D Deficiency in Relation to the Risk of Metabolic Syndrome in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus. Journal of Nutritional Science and Vitaminology, 62(4), 213–219. DOI: 10.3177/jnsv.62.213
- Akter S, Eguchi M et al (2017). Serum 25-hydroxyvitamin D and metabolic syndrome in a Japanese working population: The Furukawa Nutrition and Health Study. Nutrition, 36, 26–32. DOI: 10.1016/j.nut.2016.02.024
- Ganji V, Sukik A et al (2019). Serum vitamin D concentrations are inversely related to prevalence of metabolic syndrome in Qatari women. BioFactors. DOI: 10.1002/biof.1572
- Schmitt EB, Nahas-Neto J et al (2018). Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas, 107, 97–102. DOI: 10.1016/j.maturitas.2017.10.011
- Ganji V, Zhang X et al (2011). Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001–2006. The American Journal of Clinical Nutrition, 94(1), 225–233. DOI: 10.3945/ajcn.111.013516
- Ilaria C, Agata F et al (2017). Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future. Retrieved from https://www.mdpi.com/2072-6643/9/9/1015/htm
- Chen L-W, Chien, C-H et al (2019). Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study. BMC Gastroenterology, 19(1). DOI: 10.1186/s12876-019-1040-y
- Zhu C-G, Liu Y-X et al (2017). Active form of vitamin D ameliorates non-alcoholic fatty liver disease by alleviating oxidative stress in a high-fat diet rat model. Endocrine Journal, 64(7), 663–673. DOI: 10.1507/endocrj.ej16-0542
- Ma M, Long Q et al (2019). Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. Clinics and Research in Hepatology and Gastroenterology. DOI: 10.1016/j.clinre.2019.10.007
- Liu Y, Wang M et al (2020). Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. Life Sciences, 241, 117086. DOI: 10.1016/j.lfs.2019.117086
Titelbild: (Joenomias) Menno de Jong, www.pixabay.com
Kapitel 6.5 – Die Bedeutung von Vitamin D bei Zuckererkrankungen
- Ford ES, Bergmann MM et al (2009). Healthy Living Is the Best Revenge. Archives of Internal Medicine, 169(15), 1355. DOI: 10.1001/archinternmed.2009.237
- Soltesz G, Patterson CC, Dahlquist G, EURODIAB Study Group. Worldwide childhood type 1 diabetes incidence–what can we learn from epidemiology? Pediatric diabetes 2007;8(6):6–14
- Cadario F, Ricotti R et al (2018). Administration of vitamin D and high dose of omega 3 to sustain remission of type 1 diabetes. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29424911
- Hyppönen E, Läärä E et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001;358(9292):1500–3
- Zipitis CS, Akobeng AK. Vitamin D Supplementation in Early Childhood and Risk of Type 1 Diabetes: a Systematic Review and Meta-analysis. Archives of Disease in Childhood – Fetal and Neonatal Edition 2008;93(6):512–7
- Tuomilehto J et al. Genetic predisposition to obesity and lifestyle factors–the combined analyses of twenty-six known BMI-and fourteen known waist: hip ratio (WHR)-associated variants, Diabetologia 199; 42: 655 – 660; Ehehatt S., Neu A et al. for the DIARY Group: Diabetologie & Stoffwechsel 2006; 1
- Palomer X, González-Clemente JM et al. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes, obesity & metabolism 2008;10(2):185–97
- Alemzadeh R, Kichler J et al. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism: clinical and experimental 2008;57(2):183–91
- Martins D, Wolf M et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Archives of internal medicine 2007;167(11):1159–65
- Pittas AG, Lau J et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. The Journal of clinical endocrinology and metabolism 2007;92(6):2017–29
- Hintzpeter B, Mensink GB et al. Vitamin D status and health correlates among German adults. European journal of clinical nutrition 2007
- Sugden JA, Davies JI et al. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabetic medicine: a journal of the British Diabetic Association 2008;25(3):320–5
- Hafez M, Musa N et al (2017). Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control. In: Journal of pediatric endocrinology & metabolism. JPEM 30 (4), S. 389–394. DOI: 10.1515/jpem-2016-0292
- Verburg PE, Tucker G et al (2016). Seasonality of gestational diabetes mellitus. A South Australian population study. In: BMJ open diabetes research & care 4 (1), e000286. DOI: 10.1136/bmjdrc-2016-000286
- Zhang Y, Gong Y et al (2017). Vitamin D and gestational diabetes mellitus. A systematic review based on data free of Hawthorne effect. In: BJOG : an international journal of obstetrics and gynaecology. DOI: 10.1111/1471-0528.15060
- Gellert S, Bitterlich N et al (2017). Higher prevalence of vitamin D deficiency in German pregnant women compared to non-pregnant women. In: Archives of gynecology and obstetrics 296 (1), S. 43–51. DOI: 10.1007/s00404-017-4398-5
- Tamayo T, Rathmann W et al (2016). Prevalence of gestational diabetes and risk of complications before and after initiation of a general systematic two-step screening strategy in Germany (2012–2014). Diabetes Research and Clinical Practice, 115, 1–8. DOI: 10.1016/j.diabres.2016.03.001
- Park SK, Garland CF et al (2018). Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study. Plos One, 13(4). DOI: 10.1371/journal.pone.0193070
- Mirhosseini N, Vatanparast H et al (2017). The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients. A Meta-Analysis. In: The Journal of clinical endocrinology and metabolism 102 (9), S. 3097–3110. DOI: 10.1210/jc.2017-01024
- Ekmekcioglu C, Haluza D, Kundi, M (2017). 25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies. International Journal of Environmental Research and Public Health, 14(2), 127. DOI: 10.3390/ijerph14020127
- Tang H, Li D et al (2018). Effects of Vitamin D Supplementation on Glucose and Insulin Homeostasis and Incident Diabetes among Nondiabetic Adults: A Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology, 2018, 1–9. DOI: 10.1155/2018/7908764
- Baggerly LL, Holick MF et al (2016). Incidence rate of type 2 diabetes is 50% lower in GrassrootsHealth cohort with median serum 25-hydroxyvitamin D of 41 ng/ml than in NHANES cohort with median of 22 ng/ml. In: The Journal of steroid biochemistry and molecular biology 155 (Pt B), S. 239–244. DOI: 10.1016/j.jsbmb.2015.06.013
Unter folgendem QR-Code bzw. Webadresse können Sie den im März 2020 stattgefundenen Kongress zum Thema Diabetes streamen oder downloaden:
https://digitalewelt.spitzen-praevention.com/
Titelbild: Leo_65, www.pixabay.com
Kapitel 6.6 – Vitamin D und pulmonale Erkrankungen
- Gesundheitsreport 2018 zu Arbeitsunfähigkeiten, zuletzt geprüft am 19.02.2019
- Bergman P, Lindh AU et al (2013). Vitamin D and Respiratory Tract Infections. A Systematic Review and Meta-Analysis of Randomized Controlled Trials. In: PloS one 8 (6), e65835. DOI: 10.1371/journal.pone.0065835
- Ramos-Martínez E, López-Vancell MR et al (2018). Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNγ levels and cathelicidin expression. In: Cytokine 108, S. 239–246. DOI: 10.1016/j.cyto.2018.01.001
- Zhu B, Xiao C et al (2015). Vitamin D deficiency is associated with the severity of COPD. A systematic review and meta-analysis. In: International journal of chronic obstructive pulmonary disease 10, S. 1907–1916. DOI: 10.2147/COPD.S89763
- Færk G, Çolak Y et al (2018). Low concentrations of 25-hydroxyvitamin D and long-term prognosis of COPD. A prospective cohort study. In: European journal of epidemiology 33 (6), S. 567–577. DOI: 10.1007/s10654-018-0393-9
- Malinovschi A, Masoero M et al (2014). Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients. In: Respiratory research 15, S. 131. DOI: 10.1186/s12931-014-0131-0
- Botros RM, Abo Elyazed S et al (2018). Vitamin D Status in Hospitalized Chronically Ill Patients. In: Journal of the American College of Nutrition, S. 1–5. DOI: 10.1080/07315724.2018.1446194
- Khan DM, Ullah A et al (2017). Role of Vitamin D in reducing number of acute exacerbations in Chronic Obstructive Pulmonary Disease (COPD) patients. Pakistan Journal of Medical Sciences, 33(3). DOI: 10.12669/pjms.333.12397
- Pourrashid MH, Dastan F et al (2018). Role of Vitamin D Replacement on Health Related Quality of Life in Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985196/
- Pfeffer PE, Hawrylowicz CM (2018). Vitamin D in Asthma. Chest, 153(5), 1229-1239. DOI:10.1016/j.chest.2017.09.005
- Martineau A, Takeda A et al (2015). Vitamin D for the management of asthma. Cochrane Database of Systematic Reviews. DOI:10.1002/14651858.cd01151
- Ginde AA, Mansbach J et al (2009). Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. In: Archives of internal medicine 169 (4), S. 384–390. DOI: 10.1001/archinternmed.2008.560
- Camargo CA, Ganmaa D et al (2012). Randomized Trial of Vitamin D Supplementation and Risk of Acute Respiratory Infection in Mongolia. Pediatrics, 130(3). DOI: 10.1542/peds.2011-3029
- Urashima M, Segawa T et al (2010). Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. In: The American journal of clinical nutrition 91 (5), S. 1255–1260. DOI: 10.3945/ajcn.2009.29094
- Teutemacher H, Trötschler H et al. Pneumologie, Substitution von Vitamin D bei Patienten mit Asthma und COPD – Vitamin D-Update 2011, Berlin – https://repository.publisso.de/resource/frl:4169394-1/data
- Krishnan E, Ponnusamy V, Sekar SP (2017). Trial of vitamin D supplementation to prevent asthma exacerbation in children. International Journal of Research in Medical Sciences, 5(6), 2734. DOI: 10.18203/2320-6012.ijrms20172479
- Martineau AR, Jolliffe DA et al (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. In: BMJ (Clinical research ed.) 356, i6583. DOI: 10.1136/bmj.i6583
- Hollis BW, Wagner CL (2013). The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes. In: The Journal of clinical endocrinology and metabolism 98 (12), S. 4619–4628. DOI: 10.1210/jc.2013-2653
- Manson JAE, Cook NR et al for the VITAL Research Group (2019). Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. In: The New England Journal of Medicine 2019; 380:33-44. DOI: 10.1056/NEJMoa1809944
- Khalid AN, Ladha KS et al (2015). Association of Vitamin D Status and Acute Rhinosinusitis. Medicine, 94(40). DOI:10.1097/md.0000000000001447
- Agostoni C, Bresson JL et al. Vitamin D and contribution to the normal function of the immune system. Evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 (2015). In: EFSA Journal 13 (7), S. 4182, zuletzt geprüft am 15.06.2020
Titelbild: kalhh, www.pixabay.com
Kapitel 6.7 – Neurologie und psychiatrische Erkrankungen
- Stumpf WE, Privette TH. The steroid hormone of sunlight soltriol (vitamin D) as a seasonal regulator of biological activities and photoperiodic rhythms. The Journal of steroid biochemistry and molecular biology 1991;39(2):283–9
- Nataf S, Garcion E et al. 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. Journal of neuropathology and experimental neurology 1996;55(8):904–14
- Bemiss CJ, Mahon BD et al. Interleukin-2 is one of the targets of 1,25-dihydroxyvitamin D3 in the immune system. Archives of biochemistry and biophysics 2002;402:249–54
- Garcion E, Sindji L et al. Treatment of experimental autoimmune encephalomyelitis in rat by 1,25-dihydroxyvitamin D3 leads to early effects within the central nervous system. Acta neuropathologica 2003;105(5):438–48
- Shinpo K, Kikuchi S et al. Effect of 1,25-dihydroxyvitamin D(3) on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine. Journal of Neuroscience Research 200;62:374–82
- Tetich M, Leśkiewicz M et al. The third multidisciplinary conference on drug research, Piła 2002. Effects of 1alpha,25-dihydroxyvitamin D3 and some putative steroid neuroprotective agents on the hydrogen peroxide-induced damage in neuroblastoma-glioma hybrid NG108-15 cells. Acta poloniae pharmaceutica 2003;60(5):351–5
- Kauer H. Vitamin D in Immunologie und Onkologie – Eine Literaturstudie (Dissertation). München: LMU München; 09.02.2007
- Bivona G, Gambino CM et al (2019). Vitamin D and the nervous system. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/31142227
- Kim J-E, Cho K-O (2019). Functional Nutrients for Epilepsy. Nutrients, 11(6), 1309. DOI: 10.3390/nu11061309
- Teagarden DL, Meador KJ, Loring DW (2014). Low vitamin D levels are common in patients with epilepsy. Epilepsy Research, 108(8), 1352–1356. DOI: 10.1016/j.eplepsyres.2014.06.008
- Chaudhuri JR, Mridula KR et al (2017). Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493830/
- Offermann G, Pinto V, Kruse R (1979). Antiepileptic Drugs and Vitamin D Supplementation. Epilepsia, 20(1), 3–15. DOI: 10.1111/j.1528-1157.1979.tb04771.x
- Shaikh AS, Guo X (2018). The Impact of Antiepileptic Drugs on Vitamin Levels in Epileptic Patients. Current Pharmaceutical Biotechnology, 19(8), 674–681. DOI: 10.2174/1389201019666180816104716
- Christiansen C, Rodbro P, Sjo O (1974). Anticonvulsant Action of Vitamin D in Epileptic Patients? A Controlled Pilot Study. Bmj, 2(5913), 258–259. DOI: 10.1136/bmj.2.5913.258
- Holló A, Clemens Z et al (2012). Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study. Epilepsy & Behavior, 24(1), 131–133. DOI: 10.1016/j.yebeh.2012.03.011
- Tombini M, Palermo A et al (2018). Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control. Seizure, 58, 75–81. DOI: 10.1016/j.seizure.2018.04.008
- Degiorgio CM, Hertling D et al (2019). Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy. Epilepsy & Behavior, 94, 195–197. DOI: 10.1016/j.yebeh.2019.03.001
- Kogan MD, Vladutiu CJ et al (2018). The Prevalence of Parent-Reported Autism Spectrum Disorder Among US Children. Pediatrics, 142(6). DOI: 10.1542/peds.2017-4161
- Vinkhuyzen AAE, Eyles DW et al (2018). Gestational vitamin D deficiency and autism spectrum disorder: BJPsych Open. Retrieved from https://www.cambridge.org/core/journals/bjpsych-open/article/gestational-vitamin-d-deficiency-and-autism-spectrum-disorder/339D73DC98FF9C2672A9A099D4F0F4F6
- Cannell JJ (2017). Vitamin D and autism, what’s new? Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28217829.
- Saad K, Abdel‐Rahman A et al (2019). Retraction: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 60(6), 711–711. DOI: 10.1111/jcpp.13076
- Hollis BW, Wagner CL (2012). Vitamin D and Pregnancy: Skeletal Effects, Nonskeletal Effects, and Birth Outcomes. Calcified Tissue International, 92(2), 128–139. DOI: 10.1007/s00223-012-9607-4
- Mazahery H, Conlon CA et al (2019). A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder. The Journal of Steroid Biochemistry and Molecular Biology, 187, 9–16. DOI: 10.1016/j.jsbmb.2018.10.017
- Yi L-F, Wen H-X et al (2017). Cardiac autonomic nerve function in obese school-age children. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28506342
- Canpolat U, Özcan F et al (2014). Impaired Cardiac Autonomic Functions in Apparently Healthy Subjects with Vitamin D Deficiency. Annals of Noninvasive Electrocardiology, 20(4), 378–385. DOI: 10.1111/anec.12233
- Qiu M, Wen H-X et al (2018). Effect of vitamin D deficiency on cardiac autonomic nerve function in obese pre-school children. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/30210029
- Dogdus M, Burhan S et al (2019). Cardiac autonomic dysfunctions are recovered with vitamin D replacement in apparently healthy individuals with vitamin D deficiency. Annals of Noninvasive Electrocardiology, 24(6). DOI: 10.1111/anec.12677
- Tønnesen R, Schwarz P et al (2018). Modulation of the sympathetic nervous system in youngsters by vitamin-D supplementation. Physiological Reports, 6(7). DOI: 10.14814/phy2.13635
- Psychoreport 2019: Dreimal mehr Fehltage als 1997. (n.d.). Retrieved from https://www.dak.de/dak/bundesthemen/dak-psychoreport-2019-dreimal-mehr-fehltage-als-1997-2125486.html
- Rosen L, Knudson KH, Fancher P. Prevalence of seasonal affective disorder among U.S. Army soldiers in Alaska. Military medicine 2002;167(7):581–4
- Mersch PP, Middendorp HM et al. The prevalence of seasonal affective disorder in The Netherlands: a prospective and retrospective study of seasonal mood variation in the general population. Biological Psychiatry 1999;45(8):1013–22
- Mersch PP, Middendorp HM et al. Seasonal affective disorder and latitude: a review of the literature. Journal of affective disorders 1999;53(1):35–48
- Vieth R, Kimball S et al. Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutrition Journal 2004;3:8
- Wang J, Liu N et al (2018). Association between vitamin D deficiency and antepartum and postpartum depression: A systematic review and meta-analysis of longitudinal studies. Archives of Gynecology and Obstetrics, 298, 1045–1059(2018)
- Spedding, Simon (2014). Vitamin D and depression. A systematic review and meta-analysis comparing studies with and without biological flaws. In: Nutrients 6 (4), S. 1501–1518. DOI: 10.3390/nu6041501
- McGrath J. Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia? Schizophrenia Research 1999;40(3):173-177(5)
- McGrath J, Saari K et al. Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study. Schizophrenia Research 2004;67(2-3):237–45
- O’Loan J, Eyles DW, Kesby J, Ko P, McGrath JJ, Burne TH. Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring. Psychoneuroendocrinology 2007;32(3):227–34.
- Cui X, McGrath JJ et al. Maternal vitamin D depletion alters neurogenesis in the developing rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2007;25(4):227–32
- Kocovska E, Gaughran F et al (2017). Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism. In: Frontiers in psychiatry 8, S. 47. DOI: 10.3389/fpsyt.2017.00047
Titelbild: Sabine Zierer, www.pixabay.com
Abb. 3: DAK-Report 2018, siehe Nr. 29
Kapitel 7.1 – Erkrankungen des Herzens und der Gefäße
- Michos ED, Melamed ML. Vitamin D and cardiovascular disease risk. Current opinion in clinical nutrition and metabolic care 2008;11(1):7–12
- Abdi-Ali A, Nicholl DDm et al (2013). 25-Hydroxyvitamin D status, arterial stiffness and the renin–angiotensin system in healthy humans. Clinical and Experimental Hypertension, 36(6), 386–391. DOI: 10.3109/10641963.2013.827705
- Sunbul M (2016). Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions. Turk Kardiyoloji Dernegi Ars. 2016; 44(4): 281-288. DOI: 10.5543/tkda.2015.93237
- Gillor A, Groneck P et al. Congestive heart failure in rickets caused by vitamin D deficiency. Monatsschrift Kinderheilkunde: Organ der Deutschen Gesellschaft für Kinderheilkunde 1989;13(2):108–10
- Brunvand L, Hågå P et al. Congestive heart failure caused by vitamin D deficiency? Acta paediatrica (Oslo, Norway : 1992) 1995;84(1):106–8
- Wang TJ, Pencina MJ et al. Vitamin D Deficiency and Risk of Cardiovascular Disease. Circulation 2008;117(4):503–11
- Crowe FL, Thayakaran R et al (2019). Non-linear associations of 25-hydroxyvitamin D concentrations with risk of cardiovascular disease and all-cause mortality: Results from The Health Improvement Network (THIN) database. The Journal of Steroid Biochemistry and Molecular Biology, 195, 105480. DOI: 10.1016/j.jsbmb.2019.105480
- Gholami F, Moradi G et al (2019). The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies. BMC Cardiovascular Disorders, 19(1). DOI: 10.1186/s12872-019-1236-7
- Forman JP, Giovannucci E et al. Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension. Hypertension 2007;49(5):1063–9
- Pfeifer M, Begerow B et al. Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women. The Journal of Clinical Endocrinology & Metabolism 2001;86(4):1633–7
- Sugden JA, Davies JI et al. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabetic medicine: a journal of the British Diabetic Association 2008;25(3):320–5
- Carlin AM, Rao DS et al. Effect of gastric bypass surgery on vitamin D nutritional status. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery 2006;2(6):638–42
- Carlin AM, Yager KM, Rao DS. Vitamin D depletion impairs hypertension resolution after Roux-en-Y gastric bypass. American journal of surgery 2008;195(3):349–52
- Melamed ML, Muntner P et al. Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004. Arteriosclerosis, thrombosis, and vascular biology 2008;28(6):1179–85
- Raed A, Bhagatwala J et al. (2017). Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency. A placebo controlled randomized trial. In: PloS one 12 (12), e0188424. DOI: 10.1371/journal.pone.0188424
- Shirvani A, Holick MF et al (2019). Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial. Scientific Reports, 9(1). DOI: 10.1038/s41598-019-53864-1
- Yuan J, Jia P et al (2019). Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients. BMC Cardiovascular Disorders, 19(1). DOI:10.1186/s12872-019-1125-0
- Rai V, Agrawal DK (2017). Role of Vitamin D in Cardiovascular Diseases. In: Endocrinology and metabolism clinics of North America 46 (4), S. 1039–1059. DOI: 10.1016/j.ecl.2017.07.009
- Giovannucci E, Hollis BW et al. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Archives of internal medicine 2008;168(11):1174–80
- Dobnig H, Pilz S et al. Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality. Archives of internal medicine 2008;168(12):1340–9
- Zittermann A, Götting C et al. Poor outcome in end-stage heart failure patients with low circulating calcitriol levels. European journal of heart failure 2008;10(3):321–7
- Hsia J, Heiss G et al. Women’s Health Initiative Investigators. Calcium/vitamin D supplementation and cardiovascular eve. Circulation 2007;115(7):846–54
- Schleithoff S, Zittermann A et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. American Journal of Clinical Nutrition 2006;83(5):754–9
- Saponaro F, Saba A et al (2018). Vitamin D measurement and effect on outcome in a cohort of patients with heart failure. Endocrine Connections, 7(9), 957–964. DOI: 10.1530/ec-18-0207
- Gotsman I, Shauer A et al (2012). Vitamin D deficiency is a predictor of reduced survival in patients with heart failure; vitamin D supplementation improves outcome. European Journal of Heart Failure, 14(4), 357–366. DOI: 10.1093/eurjhf/hfr175
- Nolte K, Herrmann-Lingen C et al (2019). Vitamin D deficiency in patients with diastolic dysfunction or heart failure with preserved ejection fraction. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/30784226
- Al-Khalidi B, Kimball SM et al (2017). Erratum to: Standardized serum 25-hydroxyvitamin D concentrations are inversely associated with cardiometabolic disease in U.S. adults: a cross-sectional analysis of NHANES, 2001–2010. Nutrition Journal, 16(1). DOI: 10.1186/s12937-017-0251-8
- Censani M, Hammad HT et al (2018). Vitamin D Deficiency Associated With Markers of Cardiovascular Disease in Children With Obesity. In: Global pediatric health 5, 2333794X17751773. DOI: 10.1177/2333794X17751773
- Skaaby T, Thuesen BH et al (2017). Vitamin D, Cardiovascular Disease and Risk Factors. In: Advances in experimental medicine and biology 996, S. 221–230. DOI: 10.1007/978-3-319-56017-5_18
- Al Mheid I, Quyyumi AA (2017). Vitamin D and Cardiovascular Disease. Controversy Unresolved. In: Journal of the American College of Cardiology 70 (1), S. 89–100. DOI: 10.1016/j.jacc.2017.05.031
Titelbild: Gerd Altmann, www.pixabay.com
Kapitel 7.2 – Onkologische Erkrankungen
- Pereira F, Larriba MJ, Muñoz A (2012). Vitamin D and colon cancer. Endocrine-Related Cancer, 19(3). DOI: 10.1530/erc-11-0388
- Wu X, Hu W et al (2019). Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment. Acta Pharmaceutica Sinica B, 9(2), 203-219. DOI:10.1016/j.apsb.2018.09.002
- Robien K, Cutler GJ, Lazovich D. Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study. Cancer causes & control : CCC 2007;18(7):775–82
- Lin J, Manson JE et al (2007). Intakes of calcium and vitamin D and breast cancer risk in women. Archives of internal medicine 2007;167(10):1050–9
- Knight JA, Lesosky M et al (2007). Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control Study. Cancer Epidemiology Biomarkers & Prevention 2007;16(3):422–9
- John EM, Schwartz GG et al (2007). Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Breast Cancer Risk in a Multiethnic Population. American Journal of Epidemiology 2007;166(12):1409–19
- Abbas S, Linseisen J et al (2008). Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer–results of a large case-control study. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17974532
- Goodwin PJ, Ennis M et al (2008). Frequency of vitamin D (Vit D) deficiency at breast cancer (BC) diagnosis and association with risk of distant recurrence and death in a prospective cohort study of T1-3, N0-1, M0 BC; 2008
- Madden JM, Murphy L et al (2018). De novo vitamin D supplement use post-diagnosis is associated with breast cancer survival. Breast Cancer Research and Treatment, 172(1), 179-190. DOI:10.1007/s10549-018-4896-6
- Zhu K, Knuiman M et al (2019). Lower serum 25-hydroxyvitamin D is associated with colorectal and breast cancer, but not overall cancer risk: A 20-year cohort study. Nutrition Research, 67, 100-107. DOI:10.1016/j.nutres.2019.03.010
- Song D, Deng Y et al (2019). Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies. Aging, 11(24), 12708–12732. DOI: 10.18632/aging.102597331–347. DOI: 10.4161/derm.26738
- Gorham ED, Garland CF et al (2007). Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. In: American journal of preventive medicine 32 (3), S. 210–216. DOI: 10.1016/j.amepre.2006.11.004
- Freedman DM, Looker AC et al (2007). Prospective study of serum vitamin D and cancer mortality in the United States. In: Journal of the National Cancer Institute 99 (21), S. 1594–1602. DOI: 10.1093/jnci/djm204
- Ekmekcioglu C, Haluza D, Kundi M (2017). 25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies. International Journal of Environmental Research and Public Health, 14(2), 127. DOI: 10.3390/ijerph14020127
- Garland CF, Gorham ED (2017). Dose-response of serum 25-hydroxyvitamin D in association with risk of colorectal cancer. A meta-analysis. In: The Journal of steroid biochemistry and molecular biology 168, S. 1–8. DOI: 10.1016/j.jsbmb.2016.12.003
- Maalmi H, Walter V et al (2017). Relationship of very low serum 25-hydroxyvitamin D3 levels with long-term survival in a large cohort of colorectal cancer patients from Germany. European Journal of Epidemiology, 32(11), 961-971. DOI:10.1007/s10654-017-0298-z
- Lappe JM, Travers-Gustafson D et al (2007). Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. In: The American journal of clinical nutrition 85 (6), S. 1586–1591
- Uwe Gröber, Jörg Spitz, Jörg Reichrath, Klaus Kisters, Michael F. Holick (2013). Vitamin D: Update 2013: From rickets prophylaxis to general preventive healthcare. Dermatoendocrinol 2013 Jun 1;5(3):331-47. DOI: 10.4161/derm.26738
- Chiba A, Raman R et al (2017). Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer. In: Clinical breast cancer. DOI: 10.1016/j.clbc.2017.12.001
Titelbild: PDPics, www.pixabay.com
Kapitel 7.2.1 – Hautkrebs und Sonnenschutz
- https://www.krebsdaten.de/Krebs/DE/Content/Publikationen/Krebs_in_Deutschland/krebs_in_deutschland_inhalt.html;jsessionid=046232C5C19C14D64BDE90151A095BF4.1_cid290
- Matthews NH (2017). Epidemiology of Melanoma. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK481862/
- Veronique Bataille (2013). Melanoma. Shall we move away from the sun and focus more on embryogenesis, body weight and longevity? Medical Hypotheses 2013 Nov; 81(5): 846–850. DOI: 10.1016/j.mehy.2013.05.031
- Bataille V et al. (2005). A multicentre epidemiological study on sunbed use and cutaneous melanoma in Europe, European Journal of Cancer. 2005 Sep;41(14):2141-9
- https://www.krebsdaten.de/Krebs/DE/Content/Publikationen/Krebs_in_Deutschland/krebs_in_deutschland_node.html
- Glusac EJ. (2011). The melanoma ‘epidemic’: Lessons from prostate cancer. Journal of Cutaneous Pathology, 39(1), 17-20. DOI:10.1111/j.1600-0560.2011.01848.x
- Jürgen Tacke (2015). Das deutsche Hautkrebsscreening: Vom Ende einer Illusion; Deutscher Ärzte-Verlag, Zeitschrift für Allgemeinmedizin, ZFA 7-2015; 91 (7/8)
- Gandini S, Sera F et al (2005). Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. European Journal of Cancer, 41(1), 45–60. DOI: 10.1016/j.ejca.2004.10.016
- Gandini S, Montella M et al for CLINICAL NATIONAL MELANOMA REGISTRY GROUP (2016). Sun exposure and melanoma prognostic factors. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27073541
- Chang Y-M, Barrett JH et al (2009). Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls. International Journal of Epidemiology, 38(3), 814–830. DOI: 10.1093/ije/dyp166
- Alexander Wunsch: Die Kraft des Lichts: Warum wir gutes Licht brauchen und schlechtes Licht uns krank macht. ISBN 978-3742309112, Riva Verlag, München 2019
- Newton-Bishop JA, Beswick S et al (2009). Serum 25-Hydroxyvitamin D3 Levels Are Associated With Breslow Thickness at Presentation and Survival From Melanoma. Journal of Clinical Oncology, 27(32), 5439–5444. DOI: 10.1200/jco.2009.22.1135
- Berwick M, Armstrong B et al (2005). Sun Exposure and Mortality From Melanoma. JNCI: Journal of the National Cancer Institute, 97(23), 1791–1791. DOI: 10.1093/jnci/dji411
- Dixon K, Mason R et al (2013). Vitamin D and Death by Sunshine. International Journal of Molecular Sciences, 14(1), 1964–1977. DOI: 10.3390/ijms14011964
- Muralidhar S, Newton-Bishop J et al (2019). Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity. Cancer Research, 79(23), 5986–5998. DOI: 10.1158/0008-5472.can-18-3927
- Grigalavicius M, Moan J et al (2015). Daily, seasonal, and latitudinal variations in solar ultraviolet A and B radiation in relation to vitamin D production and risk for skin cancer. International Journal of Dermatology, 55(1). DOI: 10.1111/ijd.13065
- Reichrath J, Saternus R, Vogt T (2017). Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond. Molecular and Cellular Endocrinology, 453, 96–102. DOI: 10.1016/j.mce.2017.05.001
- Ince B, Yildirim MEC, Dadaci M (2019). Assessing the Effect of Vitamin D Replacement on Basal Cell Carcinoma Occurrence and Recurrence Rates in Patients with Vitamin D Deficiency. Hormones and Cancer, 10(4-6), 145–149. DOI: 10.1007/s12672-019-00365-2
- Some Sunscreen Ingredients May Disrupt Sperm Cell Function. (n.d.). Retrieved from https://www.endocrine.org/news-and-advocacy/news-room/2016/some-sunscreen-ingredients-may-disrupt-sperm-cell-function
- https://www.ewg.org/sunscreen/report/the-trouble-with-sunscreen-chemicals/
- Lorigo M, Martinez-De-Oliveira J et al (2019). UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2 Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries. International Journal of Molecular Sciences, 20(6), 1376. DOI: 10.3390/ijms20061376
- Lorigo M, Mariana M, Cairrao E (2018). Photoprotection of ultraviolet-B filters: Updated review of endocrine disrupting properties. Steroids, 131, 46–58. DOI: 10.1016/j.steroids.2018.01.006
- Lorigo M, Martinez-De-Oliveira J et al (2019). UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2 Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries. International Journal of Molecular Sciences, 20(6), 1376. DOI: 10.3390/ijms20061376
- Ruiz PA, Morón B et al (2016). Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome. Gut, 66(7), 1216–1224. DOI: 10.1136/gutjnl-2015-310297
- Cross SE, Innes B et al (2007). Human Skin Penetration of Sunscreen Nanoparticles: In-vitro Assessment of a Novel Micronized Zinc Oxide Formulation. Skin Pharmacology and Physiology, 20(3), 148-154. DOI:10.1159/000098701
- Lademann J, Weigmann H et al (1999). Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice. Skin Pharmacology and Physiology, 12(5), 247-256. DOI:10.1159/000066249
- Pflücker F, Wendel V et al (2001). The Human Stratum corneum Layer: An Effective Barrier against Dermal Uptake of Different Forms of Topically Applied Micronised Titanium Dioxide. Skin Pharmacology and Physiology, 14(1), 92-97. DOI:10.1159/000056396
- Leite-Silva V, Sanchez W et al (2016). Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment. European Journal of Pharmaceutics and Biopharmaceutics, 104, 140-147. DOI:10.1016/j.ejpb.2016.04.022
- Gulson B, McCall M et al (2010). Small Amounts of Zinc from Zinc Oxide Particles in Sunscreens Applied Outdoors Are Absorbed through Human Skin. Toxicological Sciences, 118(1), 140-149. DOI:10.1093/toxsci/kfq243
Titelbild: ardoramanda, www.pixabay.com
Abb. 3: Alexander Wunsch, sie Nr. 11
Kapitel 7.3 – Vitamin D auf der Intensivstation
- Braun A, Chang D et al (2011). Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill*. Critical Care Medicine, 39(4), 671–677. DOI: 10.1097/ccm.0b013e318206ccdf
- Moraes R, Friedman G et al (2015). Vitamin D deficiency is independently associated with mortality among critically ill patients. Clinics, 70(5), 326–332. DOI: 10.6061/clinics/2015(05)04
- Zapatero A, Nolla J et al (2018). Severe vitamin D deficiency upon admission in critically ill patients is related to acute kidney injury and a poor prognosis. Medicina Intensiva (English Edition), 42(4), 216–224. DOI: 10.1016/j.medine.2017.07.002
- Matthews LR, Ahmed Y et al (2012). Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. The American Journal of Surgery, 204(1), 37–43. DOI: 10.1016/j.amjsurg.2011.07.021
- Khalili H, Alizadeh N et al (2015). Serum Vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients. Journal of Research in Pharmacy Practice, 4(4), 193. DOI: 10.4103/2279-042x.167051
- Moromizato T, Litonjua AA et al (2014). Association of Low Serum 25-Hydroxyvitamin D Levels and Sepsis in the Critically Ill. Critical Care Medicine, 42(1), 97–107. DOI: 10.1097/ccm.0b013e31829eb7af
- Shojaei M, Sabzeghabaei A et al (2019). The Correlation between Serum Level of Vitamin D and Outcome of Sepsis Patients; a Cross-Sectional Study. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377223/
Titelbild: sasint, www.pixabay.com
Kapitel 7.4 – Alter (Demenz und Gebrechlichkeit)
- Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin d levels and bone mineral density: a population-based study of younger and older adults. The American journal of medicine 2004;116(9):634–9
- Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. The New England journal of medicine 1997;337(10):670–6
- Chapuy MC, Arlot ME et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women 1992;327(23):1637–42
- Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. Bmj 2003;326(7387):469
- Hirschfeld HP, Kinsella R, Duque G (2017). Osteosarcopenia. Where bone, muscle, and fat collide. In: Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 28 (10), S. 2781–2790. DOI: 10.1007/s00198-017-4151-8
- Arai H, Satake S, Kozaki K (2018). Cognitive Frailty in Geriatrics. Clinics in Geriatric Medicine, 34(4), 667-675. DOI:10.1016/j.cger.2018.06.011
- Proietti M, Cesari M (2020). Frailty: What Is It? Advances in Experimental Medicine and Biology Frailty and Cardiovascular Diseases, 1-7. DOI:10.1007/978-3-030-33330-0_1
- Erlandson KM, Guaraldi G, Falutz J (2016). More than osteoporosis. Age-specific issues in bone health. In: Current opinion in HIV and AIDS 11 (3), S. 343–350. DOI: 10.1097/COH.0000000000000258
- Laurent MR, Dubois V et al (2016). Muscle-bone interactions. From experimental models to the clinic? A critical update. In: Molecular and cellular endocrinology 432, S. 14–36. DOI: 10.1016/j.mce.2015.10.017
- Nguyen ND, Ahlborg HG et al (2007). Residual Lifetime Risk of Fractures in Women and Men. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(6):781–8
- Heike A. Bischoff-Ferrari: Fracture epidemiology in the elderly. In: Duque G, Kiel DP, editors. Osteoporosis in Older Persons. Pathophysiology and therapeutic approach. Springer 2008, page 97, ISBN 978-1-84628-697-1
- Bischoff-Ferrari HA, Can U et al (2008). Severe vitamin D deficiency in Swiss hip fracture patients. Bone 2008;42(3):597–602
- Magaziner J, Hawkes W et al (2000). Recovery from hip fracture in eight areas of function. The journals of gerontology. Series A, Biological sciences and medical sciences 2000;55(9):M498-507
- Tinetti ME, Williams CS. Falls, injuries due to falls, and the risk of admission to a nursing home. The New England journal of medicine 1997;337(18):1279–84
- Cummings SR, Kelsey JL et al. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiologic reviews 1985;7:178–208
- Birge SJ, Morrow-Howell N, Proctor EK. Hip fracture. Clinics in geriatric medicine 1994;10(4):589–609
- Cummings SR, Rubin SM, Black D. The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. Clinical orthopaedics and related research 1990;252:163–6
- Cummings SR, Nevitt MC et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. The New England journal of medicine 1995;332(12):767–73
- Stevens JA, Ryan G, Kresnow M. Fatalities and Injuries From Falls Among Older Adults—United States, 1993-2003 and 2001-2005. Morbidity & Mortality Weekly Report 2006;55(45):1221–4
- Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. The New England journal of medicine 1988;319(26):1701–7
- Bischoff-Ferrari HA, Willett WC et al (2005). Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA: The journal of the American Medical Association 2005;293(18):2257–64
- Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin d levels and bone mineral density: a population-based study of younger and older adults. The American journal of medicine 2004;116(9):634–9
- Bischoff-Ferrari HA, Dietrich T et al (2004). Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged >=60 y. The American journal of clinical nutrition 2004;80(2):752–8
- Boland R. Role of vitamin D in skeletal muscle function. Endocrine reviews 1986;7(4):434–48
- Sørensen OH, Lund B et al. Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clinical science (London 1979) 1979;56(2):157–61
- Bischoff HA, Stähelin HB et al (2003). Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. Journal of bone and mineral research. The official journal of the American Society for Bone and Mineral Research 2003;18(2):343–51
- Bischoff-Ferrari HA, Dawson-Hughes B et al (2004). Effect of vitamin D on falls: a meta-analysis. JAMA: The journal of the American Medical Association 2004;291(16):1999–2006
- Graafmans WC, Ooms ME et al. Falls in the elderly: a prospective study of risk factors and risk profiles. American Journal of Epidemiology 1996;143(11):1129–36
- Bischoff-Ferrari HA, Dawson-Hughes B et al (2004). Effect of vitamin D on falls: a meta-analysis. JAMA: The journal of the American Medical Association 2004;291(16):1999–2006
- Wong YYE, McCaul AK et al (2013). Low Vitamin D Status Is an Independent Predictor of Increased Frailty and All-Cause Mortality in Older Men: The Health in Men Study. The Journal of Clinical Endocrinology & Metabolism, 98(9), 3821–3828. DOI: 10.1210/jc.2013-1702
- Zhou J, Huang P et al (2016). Association of vitamin D deficiency and frailty: A systematic review and meta-analysis. Maturitas, 94, 70–76. DOI: 10.1016/j.maturitas.2016.09.003
- Buchebner D, Bartosch P et al (2019). Association Between Vitamin D, Frailty, and Progression of Frailty in Community-Dwelling Older Women. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/31287540
- Visser M, Lips P et al (2006). Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. The American Journal of Clinical Nutrition, 84(3), 616–622. DOI: 10.1093/ajcn/84.3.616
- Kojima G, Tanabe M (2016). Frailty is Highly Prevalent and Associated with Vitamin D Deficiency in Male Nursing Home Residents. Journal of the American Geriatrics Society, 64(9). DOI: 10.1111/jgs.14268
- Samefors M, Östgren CJ et al (2014). Vitamin D deficiency in elderly people in Swedish nursing homes is associated with increased mortality. European Journal of Endocrinology, 170(5), 667–675. DOI: 10.1530/eje-13-0855
- Annweiler C, Schott AM et al (2010). Association of vitamin D deficiency with cognitive impairment in older women: Cross-sectional study. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19794127 (52)
- McCann JC, Ames BN (2008). Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18056830X
- Wilkins CH, Sheline YI et al (2006). Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17138809
- Oudshoorn C, Mattace-Raso FU et al. (n.d.). Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer’s disease. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18503256
- Llewellyn DJ, Langa KM, Lang, IA (2009. Serum 25-hydroxyvitamin D concentration and cognitive impairment. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19073839
- Annweiler C, Llewellyn DJ, Beauchet O. (n.d.). Low serum vitamin D concentrations in Alzheimer’s disease: A systematic review and meta-analysis. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23042216
- Miller JW, Harvey D et al (2015). Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults. In: JAMA neurology 72 (11), S. 1295–1303. DOI: 10.1001/jamaneurol.2015.2115
- Wilkins CH, Sheline YI et al (2006). Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17138809
- Llewellyn DJ, Lang IA et al (2010). Vitamin D and risk of cognitive decline in elderly persons. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20625021
- Chaves M, Toral A et al (2014). (n.d.) Treatment with vitamin D and slowing of progression to severe stage of Alzheimer’s disease. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25153973
- Kuningas M, Mooijaart SP et al (2009). VDR gene variants associate with cognitive function and depressive symptoms in old age. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17714831
- Beydoun MA, Ding EL et al (2012). Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22170372
- Jia J, Zhang Y et al (2019). Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer’s disease: A randomised, double-blind, placebo-controlled trial. Journal of Neurology, Neurosurgery & Psychiatry. DOI:10.1136/jnnp-2018-320199
- Annweiler C, Fantino B et al (2012). Vitamin D insufficiency and mild cognitive impairment: Cross-sectional association. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22339714
- Annweiler C, Beauchet O (2012). Serum Vitamin D Deficiency as a Predictor of Incident Non-Alzheimer Dementias: A 7-Year Longitudinal Study. Retrieved from https://www.karger.com/Article/Abstract/334944?id=pmid:6610841
- Annweiler C, Llewellyn DJ et al (2013). (n.d.). Meta-analysis of memory and executive dysfunctions in relation to vitamin D. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23948884
- Littlejohns TJ, Annweiler C et al (2014). Vitamin D and the risk of dementia and Alzheimer disease. In: Neurology 83 (10), S. 920–928. DOI: 10.1212/WNL.0000000000000755
- Bredesen D, Amos E et al (2016). Reversal of cognitive decline in Alzheimer’s disease. Aging, 8(6), 1250-1258. DOI:10.18632/aging.100981
- Mark M. Alipio, Department of Radiologic Technology, College of Allied Health Sciences, Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Coronavirus 2019 (Covid-2019), SSRN Electronic Journal 2020. DOI: 10.2139/ssrn.3571484
Titelbild: Free-Photos, www.pixabay.com
Kapitel 8 – Vitamin D-Mangel bei Haustieren
- Rosa C, Handel I et al (2019). Vitamin D status in dogs with babesiosis. Onderstepoort J Vet Res.2019 Mar 28;86(1):e1-e5. DOI: 10.4102/ojvr.v86i1.1644
- Sanchez-Cespedes R, Fernandez-Martinez MD et al (2018). Vitamin D-Receptor-Expression in der Brustdrüse von Hunden und Beziehung zu klinisch-pathologischen Parametern und Progesteron/Östrogen-Rezeptoren. Vet Comp Oncol. 2018 Mar;16(1):E185-E193. DOI: 10.1111/vco.12371. Epub 2017 Nov 27
- Young LR, Backus RC (2016). Orale Vitamin-D-Supplementierung mit dem Fünffachen der empfohlenen Menge wirkt sich geringfügig auf die Serum-25-Hydroxyvitamin-D-Konzentrationen bei Hunden aus. J. Nutri Sci 2016 Jul 29;5:e31. DOI: 10.1017/jns.2016.23. eCollection 2016
- Jaffey AJ, Backus RC et al (2018). Serum vitamin D concentrations in hospitalized critically ill dogs. PLOS ONE March 28, 2018 https://doi.org/10.1371/journal.pone.0194062
Titelbild: Hund – Jonathan Chiemsee2016, www.pixabay.com
Abb. 1: Katze – Jonathan Sautter, www.pixabay.com
Kapitel 9 – Wo sind die sinnvollsten Quellen für Vitamin D?
- Grant WB, Holick MF (2005). Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005 Jun;10(2):94-111. Alternative medicine review: a journal of clinical therapeutic 2005;10(2):94–111
- Veugelers P, Ekwaru J (2014). A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D. Nutrients, 6(10), 4472–4475. DOI: 10.3390/nu6104472
- Heaney R, Cedric C et al (2015). Letter to Veugelers, P.J. and Ekwaru, J.P., A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D. Nutrients 2014, 6, 4472–4475; DOI:10.3390/nu6104472. Retrieved from https://www.mdpi.com/2072-6643/7/3/1688
- Vieth R, Holick MF (2018). The IOM—Endocrine Society Controversy on Recommended Vitamin D Targets. Vitamin D, 1091–1107. DOI: 10.1016/b978-0-12-809965-0.00059-8
- Deutsche Gesellschaft für Ernährung (DGE): https://www.dge.de/wissenschaft/referenzwerte/vitamin-d/
- Vieth R, Bischoff-Ferrari H et al (2007). The urgent need to recommend an intake of vitamin D that is effective. The American journal of clinical nutrition 2007;85(3):649–50
- Reichrath J (2006). The challenge resulting from positive and negative effects of sunlight: How much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer? Progress in Biophysics and Molecular Biology 2006;92(1):9–16
- Lucas RM, McMichael AJ et al (2008). Estimating the global disease burden due to ultraviolet radiation exposure. International Journal of Epidemiology, 37(3), 654-667. DOI:10.1093/ije/dyn017
- Tanning As a Source Of Vitamin D.https://www.grassrootshealth.net/blog/tanning-source-vitamin-d/
- Holick MF (2002). Sunlight and vitamin D: both good for cardiovascular health. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1495109/
- Gandini S, Sera F et al (2005). Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. European Journal of Cancer, 41(1), 45–60. DOI: 10.1016/j.ejca.2004.10.016
- Gandini S, Montella M et al for CLINICAL NATIONAL MELANOMA REGISTRY GROUP (2016). Sun exposure and melanoma prognostic factors. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27073541
- Newton-Bishop JA, Beswick S et al (2009). Serum 25-Hydroxyvitamin D3 Levels Are Associated With Breslow Thickness at Presentation and Survival From Melanoma. Journal of Clinical Oncology, 27(32), 5439–5444. DOI: 10.1200/jco.2009.22.1135
- Muralidhar S, Newton-Bishop J et al (2019). Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity. Cancer Research, 79(23), 5986–5998. DOI: 10.1158/0008-5472.can-18-3927
- Reichrath J, Saternus R, Vogt T (2017). Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond. Molecular and Cellular Endocrinology, 453, 96–102. DOI: 10.1016/j.mce.2017.05.001
- Ince B, Yildirim MEC, Dadaci M (2019). Assessing the Effect of Vitamin D Replacement on Basal Cell Carcinoma Occurrence and Recurrence Rates in Patients with Vitamin D Deficiency. Hormones and Cancer, 10(4-6), 145–149. DOI: 10.1007/s12672-019-00365-2
- Vieth R (2006). Critique of the Considerations for Establishing the Tolerable Upper Intake Level for Vitamin D: Critical Need for Revision Upwards. The Journal of nutrition 2006;136(4):1117–22
- Hathcock JN, Shao A, Vieth R, Heaney R (2007). Risk assessment for vitamin D. The American journal of clinical nutrition 2007;85(1):6–18
- Hollis BW (2005). Circulating 25-Hydroxyvitamin D Levels Indicative of Vitamin D Sufficiency: Implications for Establishing a New Effective Dietary Intake Recommendation for Vitamin D. The Journal of Nutrition, 135(2), 317–322. DOI: 10.1093/jn/135.2.317
- Kimball SM, Vieth R et al (2007). Safety of vitamin D3 in adults with multiple sclerosis. In: The American journal of clinical nutrition 86 (3), S. 645–651
- McCullough PJ, Amend J (2017). Results of daily oral dosing with up to 60,000 international units (iu) of vitamin D3 for 2 to 6 years in 3 adult males. In: The Journal of steroid biochemistry and molecular biology 173, S. 308–312. DOI: 10.1016/j.jsbmb.2016.12.009
- McCullough PJ, Lehrer DS, Amend J (2019). Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. The Journal of Steroid Biochemistry and Molecular Biology, 189, 228–239. DOI: 10.1016/j.jsbmb.2018.12.010
- Garland CF, Baggerly LL et al (2011). Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21378345
- Ekwaru JP, Holick MF et al (2014). The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteers. PLoS ONE, 9(11). DOI: 10.1371/journal.pone.0111265
- Shirvani A, Holick MF (2019). Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial. Scientific Reports, 9(1). DOI: 10.1038/s41598-019-53864-1
- Prasse A (2016). The Diagnosis, Differential Diagnosis, and Treatment of Sarcoidosis. Deutsches Aerzteblatt Online. DOI:10.3238/arztebl.2016.0565
- Traub LM et al (2014). Impact of Vitamin D 3 Dietary Supplement Matrix on Clinical Response. Retrieved from https://academic.oup.com/jcem/article/99/8/2720/2537822
- Aglipay M, Birken CS et al (2017). Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children. Jama, 318(3), 245. DOI: 10.1001/jama.2017.8708
- Carlberg C, Haq A (2016). The concept of the personal vitamin D response index. In: The Journal of steroid biochemistry and molecular biology. DOI: 10.1016/j.jsbmb.2016.12.011
- Abdollahzadeh R, Fard MS et al (2016). Predisposing role of vitamin D receptor (VDR) polymorphisms in the development of multiple sclerosis. A case-control study. In: Journal of the neurological sciences 367, S. 148–151. DOI: 10.1016/j.jns.2016.05.053
- Finamor DC, Sinigaglia-Coimbra R et al (2013). A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. In: Dermato-endocrinology 5 (1), S. 222–234. DOI: 10.4161/derm.24808
Titelbild: Daoudi Aissa, www.unsplash.com
Abb. 1: Zeichnung Peter Ruge, Copyright Akademie für menschliche Medizin
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Kapitel 10 – Sonnenlicht wirkt über Vitamin D hinaus
- Slominski AT, Zmijewski MA et al (2018). How UV Light Touches the Brain and Endocrine System Through Skin, and Why. Endocrinology, 159(5), 1992-2007. DOI:10.1210/en.2017-03230
- Mead MN (2008). Benefits of Sunlight: A Bright Spot for Human Health. Environmental Health Perspectives, 116(4). DOI: 10.1289/ehp.116-a160
- Brainard GC, Sliney D et al (2008). Sensitivity of the human circadian system to short-wavelength (420-nm) light. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18838601
- Sherri M (2015). Seasonal Affective Disorder: An Overview of Assessment and Treatment Approaches. Retrieved from https://www.hindawi.com/journals/drt/2015/178564/
- Bhatti P, Buchanan DT et al (2016). Oxidative DNA damage during sleep periods among nightshift workers. Occupational and Environmental Medicine, 73(8), 537-544
- Bhatti P, Buchanan DT et al (2017). Oxidative DNA damage during night shift work. Occupational and Environmental Medicine, 74(9), 680-683
- https://www.aerzteblatt.de/nachrichten/69902/Warum-Nachtarbeit-das-Krebsrisiko-erhoeht
- Liu D, Fernandez BO et al (2014). UVA Irradiation of Human Skin Vasodilates Arterial Vasculature and Lowers Blood Pressure Independently of Nitric Oxide Synthase. Journal of Investigative Dermatology, 134(7), 1839-1846. DOI:10.1038/jid.2014.27
- Correale J, Farez MF (2013). Modulation of multiple sclerosis by sunlight exposure: Role of cis-urocanic acid. J Neuroimmunol 2013 Aug 15;261(1-2):134-40. DOI: 10.1016/j.jneuroim.2013.05.014
- Prakash S et al (2010). The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency? Journal of Headache and Pain, 2010, 11(4), 301-7
- Taylor SL, Kaur M et al (2009). Pilot study of the effect of ultraviolet light on pain and mood in fibromyalgia syndrome. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19769472
Titelbild: Will van Wingerden, www.unsplash.com
Kapitel 11 – Mangel an Urkraft führt zum Natur-Defizit-Effekt
- Veröffentlicht von Alexander Kunst am 06.11.2019. Häufigkeit von Sport in Deutschland 2018. Retrieved from https://de.statista.com/statistik/daten/studie/158278/umfrage/haeufigkeit-von-sport-und-bewegung/
- Gesundheitsbericht des RKI aus dem Jahr 2015. https://www.rki.de/DE/Content/Gesundheitsmonitoring/Gesundheitsberichterstattung/GesInDtld/gesundheit_in_deutschland_2015.pdf?__blob=publicationFile
- http://www.gbe-bund.de/pdf/DEGS1_Koerperliche_Aktivitaet.pdf
- Pedersen L, Hojman P (2012). Muscle-to-organ cross talk mediated by myokines. In: Adipocyte 1 (3), S. 164–167. DOI: 10.4161/adip.20344
- Freiberger E, Sieber C, Pfeifer K (2011). Physical activity, exercise, and sarcopenia – future challenges. In: Wiener medizinische Wochenschrift (1946) 161 (17-18), S. 416–425. DOI: 10.1007/s10354-011-0001-z
- Ahmad T, Testani JM (2017). Physical Activity Prevents Obesity and Heart Failure. Now What Are We Going to Do About It? In: JACC. Heart failure 5 (5), S. 385–387. DOI: 10.1016/j.jchf.2017.03.006
- Lugo D, Pulido AL et al (2019). The effects of physical activity on cancer prevention, treatment and prognosis. A review of the literature. In: Complementary therapies in medicine 44, S. 9–13. DOI: 10.1016/j.ctim.2019.03.013
- Camandola S, Mattson MP (2017). Brain metabolism in health, aging, and neurodegeneration. In: The EMBO journal 36 (11), S. 1474–1492. DOI: 10.15252/embj.201695810
- Peter zu Eulenburg (2018). Weltraum: Das Gehirn verändert sich (Heute Journal). ZDF, 18.11.2018, zuletzt geprüft am 02.01.2020
- Pedersen BK, Saltin B (2015). Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases. In: Scandinavian journal of medicine & science in sports 25 Suppl 3, S. 1–72. DOI: 10.1111/sms.12581
- Ames BN (2010). Optimal micronutrients delay mitochondrial decay and age-associated diseases. Mechanisms of Ageing and Development, 131(7-8), 473-479. DOI:10.1016/j.mad.2010.04.005
- Ames BN (2018). Prolonging healthy aging: Longevity vitamins and proteins. Proceedings of the National Academy of Sciences, 115(43), 10836-10844. DOI:10.1073/pnas.1809045115
- Krug S et al (2018). Sport- und Ernährungsverhalten bei Kindern und Jugendlichen in Deutschland – Querschnitt-Ergebnisse aus KiGGS Welle 2 und Trends. Retrieved June 01, 2020, from https://edoc.rki.de/handle/176904/5687?show=full
- Calder PC (2017). Omega-3 fatty acids and inflammatory processes: From molecules to man. Biochemical Society Transactions, 45(5), 1105-1115. DOI:10.1042/bst20160474
- Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ (2019). Role of the microbiome in human development. Gut, 68(6), 1108-1114. DOI:10.1136/gutjnl-2018-317503
- Li X, Zhang Y et al (2020). Bidirectional Brain‐gut‐microbiota Axis in increased intestinal permeability induced by central nervous system injury. CNS Neuroscience & Therapeutics. DOI:10.1111/cns.13401
- Thomas Biegl: Glücklich singen. (n.d.). Retrieved June 01, 2020, from http://www.thomasbiegl.gmxhome.de/1Diplomarbeit.html
- Grape C, Sandgren M et al (2002). Does singing promote well-being?: An empirical study of professional and amateur singers during a singing lesson. Integrative Physiological & Behavioral Science, 38(1), 65-74. DOI:10.1007/bf02734261
- Thomas Blank, Karl Adamek: Singen in der Kindheit: Eine empirische Studie zur Gesundheit und Schulfähigkeit von Kindergartenkindern und das Canto elementar-Konzept zum Praxistransfer, ISBN 978-3830923749, Waxmann Verlag, Münster 2010
- Fukui H (2003). The Effects of Music and Visual Stress on Testosterone and Cortisol in Men and Women. Neuro endocrinology letters Jun-Aug 2003, 24(3-4):173-80
- Dobzhansky T (1973). Nothing in Biology Makes Sense Except in the Light of Evolution, American Biology Teacher, 35 (3): 125–129, JSTOR 4444260; reprinted in Zetterberg, J. Peter, ed. (1983), Evolution versus Creationism, Phoenix, Arizona: ORYX Press
- Yusuf S, Hawken S et al (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. The Lancet, 364(9438), 937-952. DOI:10.1016/s0140-6736(04)17018-9
- Ford et al (2009). Healthy Living Is the Best Revenge. Archives of Internal Medicine, 169(15), 1355. DOI:10.1001/archinternmed.2009.237
- Iddir M, Brito A et al (2020). Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients, 12(6), 1562. DOI:10.3390/nu12061562
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Abb. 5: Peter Ruge, Copyright: Akademie für menschliche Medizin
Abb. 7: AU-Daten der DAK-Gesundheit 1997 – 2014
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